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Natural Nootropics In Food Coluracetam BCI-540

Biopro Chemicals Co., Ltd.
Biopro Chemicals Co., Ltd.
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Province/State: Shanghai
Country/Region: China
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Natural Nootropics In Food Coluracetam BCI-540

Brand Name : Biopro
Model Number : NTP-001
Certification : GMP/HACCP/ISO
Place of Origin : China
MOQ : 10 Grams
Price : USD1~10 per Gram
Payment Terms : T/T, Western Union, MoneyGram
Supply Ability : 10 kgs per week
Delivery Time : Immediate Shipment
Packaging Details : Foil Bag, Drums
Product Name : Coluracetam
CAS No. : 135463-81-9
Other Name : BCI-540
Classification : Nootropics
Molecular Weight : 341.40
Molecular Formula : C19H23N3O3
Purity : 99% min.
Standard : Pharmaceutical Grade
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Coluracetam powder natural Nootropics CAS No. 135463-81-9 Pharmaceutical Grade MKC-231

  • Description

    Coluracetam (BCI-540; formerly MKC-231) is a nootropic agent of the racetam family. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California. Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently[when?] out-licensing the drug for this purpose. [full citation needed] It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.

    Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.

  • Specification

    Product Name: Coluracetam
    Other Name:
    BCI-540, MKC-231
    CAS #: 135463-81-9
    Purity: 99% min.
    Molecular Formula:
    Molecular Weight: 341.40

  • Purity

    Our Coluracetam has a purity not less than 99%.

  • Application Information

    Coluracetam appears to interact with a process known as high affinity choline uptake (HACU for short), which is the rate-limiting step of drawing choline into a neuron for synthesis into the neurotransmitter acetylcholine. Increasing the HACU rate appears to increase the activity of cholinergic neurons, so it is a desired target for cognitive enhancement.

    Interventions in rats (as there is no human evidence currently) support the usage of coluracetam at very low oral doses to preserve HACU that is otherwise impaired by the use of research drugs that are known to impair HACU. The limited evidence looking at the inherent effects of coluracetam on the HACU of normal neurons has failed to find any significant interaction.

    Coluracetam has also been noted to associate with choline transporters physically, but it is not known exactly what it does once associated.

    Overall, there is currently insufficient evidence to support the usage of coluracetam for cognitive enhancement. Further studies are needed to see if it has a therapeutic role in instances where HACU may be impaired (such as Alzheimer's disease).

  • Buy Coluracetam from Biopro for discount on the first order.
  • Reference List of Available Nootropics:
    CASProduct NameOther Name
    62613-82-5OxiracetamISF 2522
    15180-02-6Amfonelic AcidAFA

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