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Sunifiram Strongest Nootropic For Depression

Biopro Chemicals Co., Ltd.
Biopro Chemicals Co., Ltd.
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Sunifiram Strongest Nootropic For Depression

Brand Name : Biopro
Model Number : NTP-008
Certification : GMP/HACCP/ISO
Place of Origin : China
MOQ : 100 Grams
Price : USD1~10 per Gram
Payment Terms : T/T, Western Union, MoneyGram
Supply Ability : 10 kgs per week
Delivery Time : Immediate Shipment
Packaging Details : Foil Bag, Drums
Product Name : Sunifiram
CAS No. : 314728-85-3
Other Name : DM-235
Classification : Nootropics
Molecular Weight : 246.304
Molecular Formula : C14H18N2O2
Purity : 99% min.
Standard : Pharmaceutical Grade
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Natural Nootropics Sunifiram Powder AFA CAS No. 314728-85-3 DM-235

  • Description

    Sunifiram (DM-235) is a synthetic derivative of Piracetam, although due to breaking the pyrrolidone backbone it is no longer in the Racetam class of drugs (yet by being derived from them, it is still commonly associated with this class).

    Sunifiram has mechanisms similar to Nefiracetam in the hippocampus, and similar to that drug sunifiram shows anti-amnesiac properties and is potentially a cognitive enhancer. Its anti-amnesiac activity is several orders of magnitude greater than piracetam on a per weight basis, and preliminary evidence suggest it has a similarly low toxicity profile.

    This compound is known as an AMPAkine due to exerting most of its actions via the AMPA receptor (one of the three main subsets of glutamate receptors, alongside NDMA and kainate). This enhancement of AMPA function seems to also rely on enhancing signalling via the Glycine binding site of NMDA receptors, although one minimal signalling goes through the NMDA receptor then the benefits on AMPA receptors seem dose-dependent.

  • Specification

    Product Name: Sunifiram
    Other Name:
    CAS #: 314728-85-3
    Purity: 99% min.
    Molecular Formula:
    Molecular Weight: 246.304

  • Purity

    Sunifiram has a purity not less than 99%.
  • Application Information

    10-100nM of sunifiram has been noted to enhance NMDA-dependent signalling via an increase in PKCα phosphorylation, dependent on the glycine binding site and acting antagonistically to Glycine (300μM). This receptor activation actiates Src, and inhibiting Src inhibits the increase in long term potentiation. NMDA-depedent long-term potentiation has been confirmed in vivo with 0.01-1mg/kg oral intake of sunifiram for 7-12 days.

    While signalling via the NDMA receptor exhibited a bell-curve response peaking at 10nM it was able to cause concentration-dependent enhancement of neuronal signalling up to 1,000nM due to an increase in AMPA receptor phosphorylation. Increases in AMPA receptor activation was associated with an increase in (NMDA receptor dependent) CAMKII phosphorylation and PKCα both of which have been confirmed in vivo with 0.01-1mg/kg sunifiram oral ingestion and are blocked by a glycine-site NMDA antagonist. AMPA receptor activation has been noted elsewhere to be associated with the anti-amnesiac effects of sunifiram.

    Sunifiram injections at 0.01mg/kg are able to facilitate acetylcholine release in the prefrontal cortex of rats, with no apparent efficacy at 1mg/kg. The magnitude was around 200% of baseline within an hour of injection.

    Sunifiram is known to enhance long-term potentiation (LTP) in vitro (10-1000nM) and in vivo (0.01-1mg/kg for 7-12 days oral intake) in a manner that is initially dependent on the NMDA receptor (particularly, the glycine binding site) but then positively influences the activity of AMPA receptors.

    In olfactory bulbectomized mice with hippocampal dependent memory impairments, sunifiram at 1mg/kg is able to abolish the reductions seen when given after training sessions. LTP in these mice (normally impaired and causes memory dysfunction[8]) was also normalized to control levels.

    Amnesia induced by scopolamine, baclofen, diphenhydramine, and clonidine have all been noted to be reduced with sunifiram with injected doses as low as 0.001mg/kg and oral doses as low as 0.01mg/kg.

  • Reference List of Available Nootropics:
    CASProduct NameOther Name
    62613-82-5OxiracetamISF 2522
    15180-02-6Amfonelic AcidAFA

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