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Strongest Natural Nootropics Antidepressant NSI - 189 Powder AFA 1270138-40-3

Biopro Chemicals Co., Ltd.
Biopro Chemicals Co., Ltd.
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Province/State: Shanghai
Country/Region: China
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Strongest Natural Nootropics Antidepressant NSI - 189 Powder AFA 1270138-40-3

Brand Name : Biopro
Model Number : NTP-009
Certification : GMP/HACCP/ISO
Place of Origin : China
MOQ : 100 Grams
Price : USD1~10 per Gram
Payment Terms : T/T, Western Union, MoneyGram
Supply Ability : 10 kgs per week
Delivery Time : Immediate Shipment
Packaging Details : Foil Bag, Drums
Product Name : NSI - 189
CAS No. : 1270138-40-3
Other Name : NSI189
Classification : Nootropics
Molecular Weight : 366.50
Molecular Formula : C22H30N4O
Purity : 99% min.
Standard : Pharmaceutical Grade
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Natural Nootropics NSI - 189 Powder AFA CAS No. 1270138-40-3 NSI189

  • Description

    NSI-189 is an experimental, novel potential antidepressant that is under investigation by Neuralstem, Inc. for the treatment for major depressive disorder (MDD), as well as for cognitive impairment and neurodegeneration. Research into NSI-189 has been funded by the Defense Advanced Research Projects Agency (DARPA) and the National Institutes of Health (NIH). The mechanism of action of NSI-189 appears to be activation of neurogenesis in the hippocampus and possible enlargement of this structure, but how the drug mediates these effects is unknown and binding studies have so far failed to identify any certain molecular targets for the drug. As stated by Neuralstem, NSI-189 is a "new chemical entity with [a] novel mechanism of action, molecular target yet unknown, but not mediated by SSRI or SNRI or by BDNF release or via any known GPCRs, kinases, or channels." The drug was discovered via high-throughput screening of a library of 10,269 compounds for neurogenic effects in vitro.

  • Specification

    Product Name: NSI-189
    Other Name:
    CAS #: 15180-02-6
    Purity: 99% min.
    Molecular Formula:
    Molecular Weight: 366.50

  • Purity

    NSI-189 has a purity not less than 99%.
  • Application Information

    NSI-189 successfully completed a phase I clinical trial for MDD in 2011, where it was administered to 41 healthy volunteers. A phase Ib clinical trial for treating MDD in 24 patients started in 2012 and completed in July 2014, with results published in December 2015. Neuralstem is now preparing to initiate phase II clinical studies for MDD in the first quarter of 2016, with results expected in the second half of 2017. In the two clinical studies conducted thus far, NSI-189 has shown statistically significant effectiveness in reducing depressive symptoms, has been found to be safe and well-tolerated (with no major adverse effects observed), and has been found to improve cognitive deficits in depressed patients. In addition to MDD, Neuralstem intends to pursue clinical development of NSI-189 for a variety of other neurological conditions, including traumatic brain injury, Alzheimer's disease, post-traumatic stress disorder, stroke, and natural cognitive and memory decline in aging.

  • Reference List of Available Nootropics:
    CASProduct NameOther Name
    62613-82-5OxiracetamISF 2522
    15180-02-6Amfonelic AcidAFA

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