CAS 50-02-2 Pharmaceutical Raw Material Anti Inflammatory Steroids
Dexamethasone is used to treat conditions such as arthritis,
blood/hormone/immune system disorders, allergic reactions, certain
skin and eye conditions, breathing problems, certain bowel
disorders, and certain cancers. It is also used as a test for an
adrenal gland disorder (Cushing's syndrome).This medication is a
corticosteroid hormone (glucocorticoid). It decreases your body's
natural defensive response and reduces symptoms such as swelling
and allergic-type reactions.
1. Quick Details:
|Melting point:||262-264 °C(lit.)|
|Flash Point:||297.5 °C|
|Boiling Point:||568.2 °C at 760 mmHg|
|Alpha:||75 º (c=1, dioxane)|
|Water Solubility:||10 mg/100 mL (25 ºC|
|Appearance:||White crystalline solid|
Dexame-thasone, a corticosteroid, is similar to a natural hormone
produced by your adrenal glands. It often is used to replace this
chemical when your body does not make enough of it. It relieves
inflammation (swelling, heat, redness, and pain) and is used to
treat certain forms of arthritis; skin, blood, kidney, eye,
thyroid, and intestinal disorders (e.g., colitis); severe
allergies; and asthma. Dexamethasone is also used to treat certain
types of cancer.
Dexame-thasone comes as a tablet and a solution to take by mouth.
Your doctor will prescribe a dosing schedule that is best for you.
Follow the directions on your prescription label carefully, and ask
your doctor or pharmacist to explain any part you do not
understand. Take dexamethasone exactly as directed. Do not take
more or less of it or take it more often than prescribed by your
3. Application of Dexamethasone :
Dexamethasone wide range of applications, the role of strong,
significantly, is commonly used corticosteroids, in the rescue of
allergic diseases, shock, and other severe acute endocrine crisis
have played a key role, is indispensable clinical drugs.
Dexamethasone anti-inflammatory effects and control skin allergy
stronger than prednisone, its anti-inflammatory activity equivalent
to 0.75mg 5mg prednisone, skin allergies better. For status
asthmaticus critical situation of the disease, it may be a good
short-term high-dose intravenous dexamethasone effects, intravenous
infusion every 5 ~ 20mg, 4 ~ 6h can be repeated dosing, reduction
after 48 ~ 72h, 5 ~ 7 days withdrawal. Patients with cerebral edema
due to various reasons can be given for the first time 10mg
intravenous injection. Every 4 to 6 hours after intramuscular
injection of 2 ~ 4mg, generally can be alleviated within 24h, 48 ~
72h reductions, 7 days withdrawal.
4. What This Drug Is Used for:
As an anti-inflammatory medication. Dexamethasone relieves
inflammation in various parts of the body. It is used specifically
to decrease swelling (edema), associated with tumors of the spine
and brain, and to treat eye inflammation.
- To treat or prevent allergic reactions.
- As treatment of certain kinds of autoimmune diseases, skin
conditions, asthma and other lung conditions.
- As treatment for a variety of cancers, such as leukemia, lymphoma,
and multiple myeloma.
- To treat nausea and vomiting associated with some chemotherapy
- Used to stimulate appetite in cancer patients with severe appetite
- Also used to replace steroids in conditions of adrenal
insufficiency (low production of needed steroids produced by the
5. How Should I Take Dexamethasone?
Take dexamethasone exactly as prescribed by your doctor. Do not
take in larger or smaller amounts or for longer than recommended.
Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get
the best results.
Your steroid medication needs may change if you have unusual stress
such as a serious illness, fever or infection, or if you have
surgery or a medical emergency. Tell your doctor about any such
situation that affects you.
This medication can cause unusual results with certain medical
tests. Tell any doctor who treats you that you are using
Do not stop using dexamethasone suddenly, or you could have
unpleasant withdrawal symptoms. Talk to your doctor about how to
avoid withdrawal symptoms when stopping the medication.
Wear a medical alert tag or carry an ID card stating that you take
dexamethasone. Any medical care provider who treats you should know
that you are using steroid medication.
Store at room temperature away from moisture and heat.
|Product name||Dexamethason E|
|Appearance||White crystalline powder|
|Specific optical rotation||Between+72°and +80°||+76.4°|
|Chromatographic purity||Any individual impurity not more than 1.0% Total impurities not
more than 2.0%||0.46% 1.13%|
|Loss on drying||Not more than 0.5%||0.11%|
|Residue on ignition||Not more than 0.2%||0.06%|
|Residual solvents||Methanol¡Ü3000ppm Methylene Chloride¡Ü600ppm Chloroform¡Ü60ppm
Tetrahydrofuran¡Ü720ppm||364ppm Not detect out Not detect out Not detect out|
|Assay||Between 97.0% and 102.0%||98.1%|
|Micronixation||90% not more than 10 microns||90% not more than 10 aicrons|
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